PENGARUH PEMBERIAN EKSTRAK AIR KAYU AKWAY (Drymis piperita Hook. f.) PADA PERTUMBUHAN Plasmodium falciparum PENYEBAB MALARIA

Faizal Hermanto, Fahrauk Faramayuda

Sari


ABSTRAK

Indonesia merupakan salah satu daerah endemik malaria. Resistensi obat malaria menjadi salah satu masalah dalam pengobatan malaria, oleh karen itu diperlukan pencarian obat malaria baru. Kulit kayu akway (Drimys piperita Hook. f) secara empiris digunakan oleh Suku Sogb Manokwari Papua sebagai antimalaria  dan  afrodisiaka. Penelitian  ini  diawali  dengan  proses  pembuatan  ekstrak  air  kulit  kayu akway  dengan  metode  perebusan  menggunakan  pelarut  air  suling.  Pengujian  aktivitas  antimalaria menggunakan Plasmodium falciparum 3D7 secara in vitro. Ekstrak air kulit kayu akway menunjukan aktivitas antimalaria yang baik dengan nilai IC 50  sebesar 0,013 µg/mL.

Kata kunci : Akway, Drimys piperita Hook. f., Antimalaria, Plasmodium falciparum

 

ABSTRACT

Indonesia is one of malaria endemic areas. Malaria drug resistance is one of the problems in malaria treatment, therefore  it  is  necessary  to  search for  new  malaria  drugs.  Drimys  piperita  stem bark  is empirically used by the Sogb tribe, Manokwari Papua as antimalarial and aphrodisiac. This research begins made water extract of Drimys piperita stem bark by boiling method using distilled water as solvent. Testing of antimalarial activity using Plasmodium falciparum 3D7 in vitro. water extract of Drimys piperita stem bark showed good antimalarial activity with IC 50  value of      0,013 μg / mL.

Keywords : Drimys piperita stem bark, Antimalarial, Plasmodium falciparum


Teks Lengkap:

PDF

Referensi


Adams, Y. et al., 2005. Carrageenans inhibit the in vitro growth of Plasmodium falciparum and cytoadhesion to CD36. Parasitology Research, 97(4), pp.290–294.

Bhat, G.P. & Surolia, N., 2001. In vitro antimalarial activity of extracts of three plants used in the traditional medicine of India. The American journal of tropical medicine and hygiene, 65(4), pp.304–8. Available at: http://www.ncbi.nlm.nih.gov/pubmed/11693874.

Cepeda, G.N. et al., 2011. Komposisi Kimia Minyak Atsiri Daun Akway. Makara Sains, 15(1), pp.63–66.

Deharo, E. et al., 2001. A search for natural bioactive compounds in Bolivia through a multidisciplinary approach. Part V. Evaluation of the antimalarial activity of plants used by the Tacana Indians. Journal of Ethnopharmacology, 77(1), pp.91–98.

Fidock, D. a et al., 2004. Antimalarial drug discovery: efficacy models for compound screening. Nature reviews. Drug discovery, 3(6), pp.509–520.

Inbaneson, S.J., Sundaram, R. & Suganthi, P., 2012. In vitro antiplasmodial effect of ethanolic extracts of traditional medicinal plant Ocimum species against Plasmodium falciparum. Asian Pacific Journal of Tropical Medicine, 5(2), pp.103–106.

López, M.L. et al., 2010. Induction of cell death on Plasmodium falciparum asexual blood stages by Solanum nudum steroids. Parasitology International, 59(2), pp.217–225.

Partemoan, S., 1995. Tumbuhan Sebagai Sumber Zat Aktif Antimalaria. Bultin Penelitian Kesehatan, 23, pp.1–9.

Trager, W. & Jensen, J.B., 1976. Human malaria parasites in continuous culture. Science (New York, N.Y.), 193(4254), pp.673–5. Available at: http://www.ncbi.nlm.nih.gov/pubmed/781840.




DOI: http://dx.doi.org/10.26874/kjif.v5i1.88

Refbacks

  • Saat ini tidak ada refbacks.


Visitors Statistic

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.