KAJIAN LITERATUR DAN KROMATOGRAFI UNTUK HERBA KESUM
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ABSTRAK
Spesis Polygonum (misalnya P. aviculare) dilaporkan mempunyai kandungan alkaloid. Begitu juga dengan daun kesum (P. minus Huds), yang terbukti sebagai sumber molekul perubatan semulajadi. Masalah yang diidentifikasi dari kajian kesum termasuklah di dalam aspek fitokimia genus Polygonum ini, yang belum pernah disiasat secara mendalam. Oleh itu, sasaran kajian ini adalah untuk mengulas data biokimia tumbuhan tersebut melalui metode literatur serta menjalankan telaah analisis kimia terhadap ekstrak kesum. Dari artikel dan jurnal penerbitan, bahagian daun dan akar dipelajari melalui kaedah kromatografi kolom. Tambahan itu, sebatian kimia dari kesum dicirikan dengan teknik spektroskopi resonans magnetik nuklear. Temuan signifikan diperolehi apabila senyawa indol dan alkaloid diterpen C20 berjaya dikarakterisasi. Secara kesimpulannya, projek di masa hadapan boleh ditumpu kepada ujikaji antikanser dan anti-penuaan dari herba kesum ini.
Kata kunci : herba, kesum, literatur, Polygonum
ABSTRACT
Polygonum species (e.g. P. aviculare) were reported to consist of alkaloidal nature. Likewise, the kesum leaves (P. minus Huds) is proven as a source of natural medicinal compound. The identified problem in the kesum research would include the phytochemistry aspects of this Polygonum genus, which is not yet thoroughly investigated, via literature search. Therefore, the aim of this study is to accumulate and review the biochemical data of this herb. From the articles and published journals, the leaves and root extracts were analysed by using liquid chromatographic technique. In addition, the chemical substance from kesum could be elucidated via nuclear magnetic resonance spectroscopy. The significant findings could be obtained when the indole and and C20-diterpene alkaloids were successfully characterised. In summary, future directions of the project could focus on anticancer and anti-aging experiments of this kesum herb.
Keywords : herb, kesum, literature, Polygonum
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