Formulasi Dan Evaluasi Transdermal Patch Kalium Diklofenak
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Abstrak
Kalium diklofenak adalah salah satu obat golongan anti-inflamasi non steroid (AINS) yang memberikan efek samping iritasi pada saluran pencernaan. Tujuan penelitian ini adalah melakukan formulasi dan evaluasi sediaan dengan rute alternatif lain penggunaan kalium diklofenak melalui transdermal patch. Patch dibuat dengan metode penguapan pelarut. Polivinil pirolidon (PVP) digunakan sebagai polimer untuk pembentukan patch transdermal kalium diklofenak dengan dibutil ftalat (DBP) sebagai plasticizer dan mentol sebagai peningkat penetrasi. Uji in vitro dilakukan dengan alat difusi modifikasi Franz dan ditentukan dengan spektroskopi UV-sinar tampak. Kadar zat aktif, berat, ketebalan dan organoleptis dari patch juga ditentukan. Hasil penelitian menunjukan bahwa rata-rata uji laju difusi sediaan patch 1,3884 mg/cm2 dengan persen permeasi sebesar 8,9 % selama 180 menit.
Kata Kunci : Transdermal; Patch; kalium diklofenak; mentol.
Formulation and Evaluation Patch Transdermal Diclofenac Potassium
Abstract
Diclofenac potassium is one of the non-steroidal anti-inflammatory drugs (NSAIDs) that provides irritating side effects to the digestive tract. The purpose of this study is to formulate and evaluate preparations with alternative routes of using potassium diclofenac through the transdermal patch. Preparation of the matrix patches used the solvent casting method. Polyvinyl pyrrolidone (PVP) was used as a matrix for the formation of transdermal diclofenac potassium patches, dibutyl phthalate (DBP) as the plasticizer and menthol as the permeation enhancer. The in vitro assay was carried out in a modified Franz diffusion cell and the rates of diffusion were determined by UV spectroscopy. The average drug content, thickness, organoleptic, weight uniformity of the matrix patches was also determined. The results showed that the average dosage rate of diffusion test Patch is 1,3884 mg/cm2 with permeation percentage 8,9 % for 180 minutes.
Keywords: Transdermal; Patch; diclofenac potassium; menthol
Chien, Y, W, 1987, Transdermal Controlled Systemic Medication, Vol.31, Marcel dekker inc, New York,
Gan, Sulistia, 2007, Farmakologi dan Terapi, Edisi V, Gaya baru, Jakarta, Hlm 230
Gungor, sevgi, Sedef Erdal dan Yıldız Özsoy. 2012. Plasticizers in Transdermal Drug Delivery Systems. In tech.
JECFA (2001). Ethyl Cellulose.
Kamal, Amira dkk. 2016. A Review On Uv Spectrophotometric Methods For Simultaneous Multicomponent Analysis. ejpmr, 3(2), 348-360
Kusumawati, 2002, Penghambatan Siklooksigenase-2: Obat Analgesik Antiinflamasi Non Steroid (AINS) Masa depan, Volume 2(1), MutiaraMedika, Yogyakarta, Hlm 29
Lahora, Daleshwari, Vandana Chaudhary, Saurabh Kumar Shah, Gaurav Swami Giridhari Chaudhary, Shubhini A, Saraf Giridhari, Chaudhary dan Shubhini A, Saraf, 2011, Terpenes: Natural Skin Penetration Enhancers in Transdermal Drug Delivery System,.
Mardolcar UV, CA nieto de Castro, FJV Santos. 1992. Dielectric Constan Measurement of Toluene and Benzene. Elservier Science, 79; 255-264
Martini, F.H., 2006, Fundamentals of Anatomy and Physiology, 6thed, Prentice Hall Inc, New Jersey, Hlm 154-163
Matsui, horofumi dkk. 2011. The pathophysiology of nonsteroidal anti inflammatory drug (NSAID)induced mucosal injuries in stomach and small. J. Clin. Biochem. Nutr. | March 2011 | vol. 48 | no. 2 | 107–111
Mc. Evoy G.K., 1999. America Hospital Formulary Servise (AHFS): Drug Information, ASHP, USA, Hlm 1700
Philips, C.M., Transdermal Delivery of Drugs with Differing Lipophilicities Using Azone Analogs as Dermal Penetration Enhancers, J,Pharm,Sci, 1995, Hlm 84(12), 1427-1433
Rajabalaya, Rajan, Jasmina Khanam dan Arunabha Nanda, 2008, Design of a matrix Patch formulation for long-acting permeation of diclofenac potassium, Asian Journal of Pharmaceutical Sciences 2008, 3 (1): 30-39
Rajan, R., dkk. 2010. Design and in vitro evaluation of chlorpheniramine maleate from different eudragit based matrix patches: Effect of platicizer and chemical enhancers. Ars Pharm 50(4): 177-194.
Ramawati, D., Medikasi, 2009, Available at: http://www.unsoed.ac.id/newc msfak/UserFiles/File/FKIK/medikasi.html, (diakses pada tanggal 9 Desember 2011, Pukul 20,00 WIB)
Sheth, Nirav S. dan Rajan B Mistry, 2011, Formulation and evaluation of transdermal Patches and to study permeation enhancement effect of eugenol, Journal of Applied Pharmaceutical Science 01 (03)
Sweetman, Sean C., 2007, Martindale: The Complete Drug Reference, 35th edision, Pharmaceutical Press, London, Chicago.
